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[DOI] [PubMed] [Google Scholar] 272.Paixao C., Dias C.M., Jorge R., Carraca E.V., Yannakoulia M., de Zwaan M., Soini S., Hill J.O., Teixeira P.J., Santos I

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Meta-analysis conducted by Cui and coauthors which included 761 esophageal and gastric cancer cases and 457 controls demonstrated a strong association of PLCE1 expression with tumor progression in esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) [27]

It has been widely used for years and is often chosen for its well-studied safety profile and consistent results when combined with lifestyle changes